CALCIUM REGULATION OF EGF-INDUCED ERK5 ACTIVATION: ROLE OF LAD1-MEKK2 INTERACTION.

The ERK5 cascade is a Body Sunscreen MAPK pathway that transmits both mitogenic and stress signals, yet its mechanism of activation is not fully understood.Using intracellular calcium modifiers, we found that ERK5 activation by EGF is inhibited both by the depletion and elevation of intracellular calcium levels.This calcium effect was found to occu

Background: The Brugada Electrocardiographic Indices Registry is a comprehensive data registry composed of patients with Brugada patterns on the electrocardiogram (ECG).The aim is to test the hypotheses that (i) ECG indices combining both depolarization and Seven Deadly Sins repolarization abnormalities can better predict spontaneous ventricular ar